Market opportunity for Acute Kidney Injury (AKI)

• AKI has become a nosocomial disease with an incidence of 5-7% in hospitalized patients
  • Surgery (especially post cardiac surgery)
  • Contrast-studies
• 5-24-billion-dollar annual cost
• Mortality of 45-70%
• AKI is increasingly recognized in COVID-19 patients

ACE2 variant protects against AKI in the mouse model of ischemia reperfusion

• This preliminary work was presented at the meeting of the American Society of Nephrology in November of 2019